Greg Sain, 2002 Bowman; Greg played in the Padres system from 2001 to 2005.
Luis Salazar, 1987 Topps; Luis played in 704 games for the Padres from 1980-1984, again in 1987 and again in 1989.
Keyvius Sampson, 2010 Bowman Platinum; Keyvius has played in the Padres system from 2009 to now is currently playing at AAA El Paso.
Reggie Sanders, 1999 Keebler; Reggie played in 133 games for the Padres in 1999.
Scott Sanders, 1993 Fleer Ultra; Scott pitched in 118 games from 1993 to 1996 and in 1998.
Benito Santiago, 1988 Fleer Baseball's Exciting Stars; Benito played in 789 games for the Padres from 1986 to 1992.
Al Santorini, 1970 Topps; Al pitched in 74 games for the Padres in 1969 and 1970.
Rick Sawyer, 1977 Topps; Rick pitched in 69 games for the Padres in 1976 and 1977.
Hall of Famers-7
Sets of Brothers-9
Didn't play for the Padres-109